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It passes through the gastrointestinal tract without damage, can be absorbed intact via the intestinal wall and also overcome the blood-brain barrier
Rapamycin treatment for amyotrophic lateral sclerosis: Protocol for a phase II randomized, double-blind, placebo-controlled, multicenter, clinical trial (RAP-ALS trial)
Hence, Smartamine is resistant to the rumen pH, but is soluble in lower pHs, such as the post-ruminal environment, being undegradable in the rumen and immediately released in the abomasum
Cells 9
doi: 10.1038/s41418-020-00685-9, 9 BaoW
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