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The hepatic damage caused by APAP is due to the production of its toxic metabolite, NAPQI, which is produced by cytochrome P450 2E1 (CYP2E1)
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Arthritis Res Ther (2018) 20(1):114
Ali SK, Makeen HA, Khuwaja G, Alhazmi HA, Sharma M, Koty A, Mazahirul I, Parveen H, Mohammed A, Mukhtar S, Alam MF (2023) Assessment of the phytochemical profile, antioxidant capacity, and hepatoprotective effect of Andrographis paniculata against CCl4-induced liver dysfunction in Wistar Albino rats
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