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Recent studies have confirmed the efficacy of Arg depletion in various ASS1-deficient xenograft tumor models, including HCC, melanoma, small-cell lung cancer (SCLC), and pancreatic cancer [278,279,280]
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Furthermore, GLP-1RA treatment in patients with T2DM has been linked to decreased secretion of pro-inflammatory cytokines, such as interleukin-1 (IL-1), interleukin-6 (IL-6) and tumor necrosis factor- (TNF-) by peripheral blood mononuclear cells (PBMC) [75]
They are usually uniform in color and sun exposure is not an etiology
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