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This modification enhances its biological activity, resulting in a higher affinity for the IGF-1 receptor and a lower affinity for IGF-binding proteins compared to endogenous IGF-1

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For example, in the STEP trials with semaglutide, participants lost up to 17% of their body weight over 68 weeks

Optimization of aqueous extraction of polyphenols from Cuminum cyminum seeds using response surface methodology and assessment of biological activity