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Patients should be encouraged to report any new or worsening abdominal pain, particularly if it differs in character from their usual medication-related side effects

And while sunscreen helps, wearing protective clothing, such as a broad-brimmed hat and long sleeves, is a better strategy to minimize the risk of drug-induced sunburns

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Future intervention studies should use placebo-controlled designs with identical excipients to eliminate this bias

Ghrelin, which promotes wakefulness and is suppressed by tirzepatide, creates a complex interplay between appetite signaling and sleep-wake regulation