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Heres why: Most routine drug tests (like urine or saliva panels used by employers or athletic agencies) are designed to detect specific categories of substances such as: Opiates THC (cannabis) Amphetamines Cocaine Benzodiazepines These tests identify metabolites or chemical signatures linked to substances that may impair function or violate policy
For this reason, NAD + and SAM observations are best treated first as pathway-engagement data, and only secondarily as safety-relevant information when paired with appropriate monitoring endpoints
10.1016/j.ejmech.2018.09.027 301 WangX.-M.LiuX.-M.WangY.ChenZ.-Y
The authors were explicit that human RCT data were absent at the time of publication
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