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The Log Rank Mantel-Cox comparison among the three groups was statistically significant, with a p-value of 0.045

Neurological symptoms, such as numbness or tingling in the hands and feet, difficulty walking, and memory problems, are also symptoms

Common signs include tiredness, memory issues, pale skin, mood changes, and tingling in the hands or feet

Because in the end, that's the only form that truly matters

The maintenance frequency approach represents hybrid strategy where initial intensive treatment (daily application for 3-6 months) establishes improvements, then reduces to maintenance schedule (2-3 times weekly or every other day) rather than complete discontinuation