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Retatrutide has received attention for strong clinical trial results, but it is not currently FDA-approved

Furthermore, this improvement was not permanent and, after six months of administration, only one (6.2%) participant continued to experience skin tone reduction

Preclinical models indicate that GLP-1 receptor activation can influence the gut-brain axis as well as the hypothalamic-pituitary-adrenal (HPA) axis, with possible implications for stress regulation and energy homeostasis[11]

The most pronounced improvements in BC were observed after 3 and 6 months of treatment, whereas after 12 months these beneficial effects tended to diminish