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GLP-1 is degraded by DPP-IV within minutes, while SEMA G due to modification at position 8 (Aib), C-18 fatty acid acylation and PEG spacer has a half-life of days in animal models
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Presented for research literature review only Rizk YS et al
However, tirzepatide has significantly longer half-life than NNC0090-2746 in humans (120 hours vs
IU = insulin units on a U-100 syringe
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