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In series of complex degradation reactions of hydro- and dihydro-peroxides of polyunsaturated fatty acids, many other aldehydes are produced: 4-hydroxy-alkenals, 4-hydroperoxy-alkenals, 4-oxo-alkenals and bis-aldehyde malonaldehyde (MDA) 28

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In this pilot proposal, using advanced edited magnetic resonance spectroscopy, the investigators will assess GABA and glutathione in the brain motor cortex of 10 FA subjects and 10 age-matched controls