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A clinical review noted that orally administered glutathione "cannot be relied upon for therapeutic purposes," which is why researchers and clinicians have used precursor strategies (NAC, GlyNAC) or IV delivery to achieve meaningful systemic increases

This severe glutathione deficit was accompanied by elevated ventricular lactate, a clear biomarker indicating that the brains of these patients are relying on highly inefficient, oxygen-deprived anaerobic metabolism due to mitochondrial stress

Phenyl isothiocyanate was then treated with Compound 20 and afforded the pyrazolo-pyrimidinone ring-containing Compound 21 , which was treated with a substituted benzyl halide to afford Compound 22

Glutathione, on the other hand, tackles oxidative stress that accelerates aging