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Acknowledgements The authors thank the following funding sources: NIDA and NIAAA Intramural Research Programs (L.L
In the absence of intracel-lular nucleophiles such as GSH, this reactive metabolite ( N -acetylbenzoiminoquinone) reacts with nucleophilic groups of cellular proteins, resulting in hepatotoxicity.The chemical and toxicologic characterization of the electro-philic nature of the reactive acetaminophen metabolite has led to the development of effective antidotescysteamine and N -acetylcysteine
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Take ghrelin for instance, a peptide connected to hunger that will affect sleep and the release of growth hormone
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