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This pipeline indicates that the performance ceiling for peptide-based obesity therapeutics has not yet been reached, sustaining investor and commercial expectations well into the 2030s

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Severe gastrointestinal reactions also open the route to the labeled warning on acute kidney injury due to volume depletion, which has included cases requiring haemodialysis in patients treated with this drug class

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Being the proximal tubule a major target for many nephrotoxicants, it is logical that cell-based in vitro models that seek to resemble this segment of the nephron should be characterized by the expression of important markers, including SLC22A6 (OAT1), SLC22A8 (OAT3), SLC22A2 (OCT2) on the basolateral membrane and ABCB1 (P-gp), SLC47A1 (MATE1), SLC47A2 (MATE2), ABCC2 (MRP2), ABCC4 (MRP4), ABCG2 (BCRP), and the endocytosis receptors megalin and cubilin on the apical membrane (Bajaj et al