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Joint stress reduction occurs mechanically as body weight decreases
Given the excellent evidence for whole-food diets, exercise in PCOS and metformin, combining these with inositol is an attractive option
[17] For higher-risk patients, a 24-hour clear-liquid diet may be recommended rather than extended solid-food fasting
Conversely, those with variants associated with lower GLP-1 pathway engagement may be candidates for combination evaluationbut only after comprehensive cardiovascular clearance
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