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The final sections of this review synthesize these insights into a strategic framework for distinguishing between failed biology and failed pharmacology, and outline regulatory, commercial, and practical considerations for advancing underexplored peptidereceptor systems toward clinical translation
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Another major limitation is that Semaglutide isnt a magic fix
P5 increased glucoregulatory efficacy could not be attributed to an enhanced insulinotropic effect, as P5 secretagogue activity was significantly decreased compared with Ex4 suggesting that additional and distinct mechanisms might contribute to improve glycaemia
Magoulas PL, El-Hattab AW
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