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Tesamorelin specifically targets visceral adipose tissue in the abdominal region, the deep fat that wraps around organs and drives metabolic risk
This observation is particularly important because it demonstrates that these drugs can remain effective even in the absence of the MC4R pathway, which is traditionally thought to play a key role in regulating energy balance and appetite
The included trials did not provide enough data to compare GLP-1 analogues and sitagliptin regarding major cardiovascular events
Background on GLP-1 RAs Ozempic, a brand name for an injectable form of the drug semaglutide, was manufactured by the multinational pharmaceutical company Novo Nordisk and initially designed to treat patients with type-2 diabetes
In a study published in the Journal of the American Medical Association Psychiatry, people with alcohol use disorder who took a low dose of semaglutide cut their consumption by roughly 50% more than those taking a placebo
