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Animal Model:Male SpragueDawley rats [3] Dosage:0.1, 0.5, 1, and 5 mg/kg Administration:Subcutaneous injection
At the end of the study, the authors observed improved dermal density, reduced periorbital wrinkles, and skin smoothness in the treatment group
The receptor is occupied but the downstream signal is weak
It is essential to discuss any concerns with your healthcare provider
Endogenous GLP-1 has a short half-life (23 minutes) and is rapidly metabolised after its secretion via the enzyme dipeptidyl peptidase (DPP-4), while GLP-1RAs have a prolonged half-life of approximately 7 days [2, 3], resulting in some long-lasting effects
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