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Authors contributions Designed and conducted the study, performed data acquisition and analysis, and wrote the manuscript: Zhang W, Xue J Collected and managed data: Wang J, Ni D, Zhou W Performed data management: Wang B, Shi J Conceived and designed the study, conducted it, interpreted the data, and revised the manuscript: Wang A All the authors have read and approved the final version of this manuscript

Examples include: Loratadine + pseudoephedrine (Claritin-D) Cetirizine + pseudoephedrine (Zyrtec-D) Since people with allergic rhinitis often take one or more of these medications daily, it is important to know if they interact with semaglutide

Rotating Injection Sites to Prevent Tissue Damage Site rotation prevents lipohypertrophy, an uncommon but significant complication where repeated injections cause fatty tissue to thicken or atrophy

The TRIUMPH-4 Phase 3 trial showed 28.7% average weight loss with retatrutide 12 mg at 68 weeks, compared to 14.9% to 17.4% with semaglutide 2.4 mg across STEP trials

Abdominal pain and discomfort Abdominal pain was reported in clinical trials at rates modestly above placebo