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It is a mucin precursor and has been shown to increase the production of mucus within the GI tract
Novo Nordisks response suggested that those figures did not take into account the resources spent in the years of research and development, stating it spent $10 billion on development of GLP-1 drugs
Gastrointestinal adverse events were common, with nausea and decreased appetite reported more frequently in the semaglutide group
Obesity is a major risk factor for high blood pressure, so by promoting weight loss, semaglutide often leads to a meaningful drop in blood pressure, including for people whose readings remain high despite taking blood pressure medications
The exception was higher BMI, which showed a stronger association with lower discontinuation rates among GLP-1 receptor agonist users than SGLT2 inhibitor users
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