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Course Description GLP-1 receptor agonists (GLP-1As) treat diabetes by increasing insulin secretion and decreasing glucagon secretion, while also slowing gastric emptying and regulating appetite, which can reduce food intake and increase satiety

Obesity is associated with low-grade systemic inflammation, characterized by increased levels of inflammatory markers such as Toll-like receptor 4 (TLR4), tumor necrosis factor-alpha (TNF-), IL-6, IL-1 [36], IL 17, leptin [37], and resistin [38]

Low GSH, neutrophil infiltration, myeloperoxidase activity and inflammation increase oxidative stress overwhelming the antioxidant defense, and hypochlorous acid mediated GSH oxidation and its attachment to proteins contribute to further GSH deficiency (114)

A specific set of criteria known as Rome III is widely used for diagnosing functional gastrointestinal disorders, including constipation and constipation-predominant irritable bowel syndrome (IBS-C) (Drossman 2006)

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