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Additionally, further research is needed to explore the broader therapeutic potential of these agents in managing comorbidities such as cardiovascular disease, PCOS, CKD, MASH, and osteoarthritis
55 R Core Team (2017)
DECLARE-TIMI 58 (Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes) assessed cardiovascular outcomes associated with dapagliflozin 10 mg daily
The interaction occurs in different tissues (pancreas, brain, myocardium, endothelium, kidney, digestive system), which means that its actions, including glycemic control with minimum risk of hypoglycemia, have a pleiotropic character (Fig
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