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8-OHdG ( )
Phase II Jastreboff 2023 NEJM: -24.2% at 12mg/48w for retatrutide vs SURMOUNT-1 Jastreboff 2022: -20.9% at 15mg/72w for tirzepatide
Week 5-8: Most GI symptoms resolve
Any perceptual disturbance during tirzepatide use requires immediate medical attention and likely medication discontinuation
The accord includes provisions requiring certain TransCon technology-based products to be identified and advanced in metabolic diseases to maintain exclusivity in the field and additional provisions for cardiovascular diseases
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