In general, under physiological conditions, substances can cross the BBB through five pathways, including passive diffusion, carrier-mediated transport, adsorptive-mediated transcytosis, adsorptive-mediated transcytosis, and efflux pumps[31, 32] (Fig
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The first published clinical trial of NAC for AUD found that relative to placebo, 28-days of NAC treatment significantly decreased drinks per drinking day, though not number of heavy drinking days, in individuals with AUD (Morley et al
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