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These reactions are typically short-lived and resolve on their own [14]
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In cases of methotrexate hepatotoxicity, vitamin B12 supplementation counteracts the decrease in vitamin B12 levels and mitigates liver damage [150]
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NNMT is a metabolic enzyme that regulates cellular energy and methylation potential by preventing NAM (Nicotinamide) from participating in the NAD+ Salvage Pathway and converting back into NAD+
