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Acta Pharm Sin B 11:23962415 Sumida Y, Yoneda M (2018) Current and future pharmacological therapies for NAFLD/NASH

Semaglutide generally produces greater metabolic improvement, but metformin remains valuable: Much lower cost makes it accessible regardless of insurance Decades of safety data Can be combined with semaglutide for enhanced effect Appropriate first-line option when cost is prohibitive Many providers use both medications, starting metformin for initial treatment and adding semaglutide when additional improvement is needed or when weight loss is a priority