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The standard titration schedule starts at 2.5 mg per week for 4 weeks, then increases to 5 mg per week for another 4 weeks, with subsequent increases of 2.5 mg every 4 weeks up to a maximum of 15 mg per week (Mounjaro prescribing information, Eli Lilly)
One of the earliest biochemical changes seen in PD is a decrease in the levels of total GSH which occurs even before a reduction in mitochondrial complex 1 activity, dopamine levels, or the neurodegeneration that are all associated with the disease (Smeyne and Smeyne, 2013)
Improved Hydration Dehydration is frequently mistaken for hunger
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