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10.1083/jcb.48.3.473 J

Their primary mechanisms of action include: Enhancing insulin secretion from pancreatic beta cells in a glucose-dependent manner, which helps lower blood sugar levels with a low risk of hypoglycaemia when used alone (though risk increases when combined with insulin or sulfonylureas) Suppressing glucagon release from pancreatic alpha cells, reducing hepatic glucose production Slowing gastric emptying , which prolongs the feeling of fullness after meals Acting on appetite centres in the brain , particularly the hypothalamus, to reduce hunger and food intake These combined effects result in improved glycaemic control for people with diabetes and significant weight loss

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FDA prescribing information Wegovy (semaglutide) Most common adverse reactions for semaglutide 2.4 mg including nausea, diarrhea, vomiting, constipation, abdominal pain, headache, fatigue, dyspepsia, and injection-site reactions