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A meta-analysis of 5 RCTs 42,43,44,45,46 comprising 7,732 adults with T2DM did not observe any effect on cognition, as measured via mini-mental state examination (MMSE) or Montreal cognitive assessment (MoCA), of GLP-1RAs over several months compared with the baseline 38
While Ozempic and Wegovy will be fairly similar since they are both Semaglutide GLP-1, Mounjaro differs slightly in that much higher doses are required for use as a weight loss medication and is the newest on the market of these options, but comes with almost the same risks and side effects
Suicidality concerns: what we know now Regulatory reviews by the FDA and EMA have not found evidence that GLP-1s cause suicidal thoughts or behaviors, though monitoring continues (FDA, 2024
The Trap: If you shut off your stomach acid while food is sitting in a slow-moving stomach, the food doesn't digest properly
Do not stop Rybelsus without consulting your prescriber, as abrupt discontinuation can worsen glycaemic control
