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Endothelial injury generated directly by intracellular viral replication and by ACE2 downregulation, exposing cells to angiotensin II in the absence of the modulator effects of angiotensin 17 (Vinciguerra et al., 2020), and vascular chronic inflammation promoting the development of tissue macrophages overloaded by cholesterol (foam cells), both increase the possibility of acquiring a severe COVID-19 infection (Vinciguerra et al., 2020

Lifestyle medicine focuses on six pillars: nutrition, physical activity, stress management, social connections, healthy sleep, and avoidance of risky substances such as alcohol and tobacco

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The FDA's Category 2 classification makes clinical development in the United States more difficult, not less

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