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While single-cell RNA sequencing and spatial transcriptomics have shed light on transcriptional heterogeneity in the PDAC stroma, parallel proteomic studies at single-cell resolution are critical for directly analyzing functional protein networks and identifying molecular signatures that differentiate malignant and stromal lineages within the tumor microenvironment [421]
In-house preparation of hydrogels for batch affinity purification of glutathione S -transferase tagged recombinant proteins
On the other hand, the most targeted strategy involves hypoxia-activated prodrugs (HAPs) [490, 491] designed for the hypoxia-ROS microenvironment
World journal of gastroenterology , 23 (48), 8465-8488
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