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Results Timeline: Noticeable results are typically visible around 4 weeks after treatment

Indicators used to determine the signalling profile of peptides include cAMP and intracellular Ca 2+ mobilisation, which are involved in promotion of insulin release, and pERK1/2 that is part of the mitogenic signalling pathways activated via the GLP-1R 12

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PMID: 41770566, PMCID: PMC12954541, DOI: 10.1001/jamanetworkopen.2026.0374

Surprisingly, we still detected an induction effect of DMF on most of the factors studied despite NRF2 silencing (Fig