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In women with an intact uterus, progesterone is required to prevent endometrial hyperplasia and reduce cancer risk [28]

(2021) The discovery of two novel classes of 5,5-bicyclic nucleoside-derived PRMT5 inhibitors for the treatment of cancer, J

Cyclization of 1) Preparation of cyclization reagent: dissolving iodine per gram in 30-40mL ethanol 2) Preparation of Vc reagent: dissolving Vc per gram in 20-30mL of purified water 3) Cyclization: the linear crude peptide was dissolved in 20% acetonitrile aqueous solution (1g of crude linear peptide in 100mL of 50% acetonitrile aqueous solution), and the linear peptide was dissolved and diluted to 1g/L with purified water

Conklin DJ, Haberzettl P, Prough RA, Bhatnagar A: Glutathione-S-transferase P protects against endothelial dysfunction induced by exposure to tobacco smoke