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Early Phase 3 data on retatrutide (triple agonist) shows pronounced appetite suppression beginning as early as week 2-4, with some patients reporting more complete food noise elimination than with semaglutide alone
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de Mello AH, Schraiber RB, Goldim MPS, Garcez ML, Gomes ML, de Bem Silveira G, Zaccaron RP, Schuck PF, Budni J, Silveira PCL, Petronilho F, Rezin GT (2019) Omega-3 fatty acids attenuate brain alterations in High-Fat Diet-Induced obesity model
Providers should approach GLP-1 therapy the way they approach antihypertensives or statins: as long-term tools for a chronic condition, with discontinuation decisions made based on clinical indication rather than an arbitrary treatment timeline
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