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Vitamin D inhibition of pro-fibrotic effects of transforming growth factor beta1 in lung fibroblasts and epithelial cells
The inflammatory microenvironment reduces the glutamate uptake, inducing accumulation of this excitatory amino acid and excitotoxic neurodegeneration
This aligns with the tissue repair timeline seen in animal studies -- rapid angiogenesis and growth factor activity in weeks 1-2, followed by remodeling through week 8 (Sikiric et al., 2006)
Food Res Int 164, 112386
More recent DSIP and DSIP-analogue research, involving modified compounds designed to behave similarly to DSIP, has explored possible neuroprotective and stroke-recovery roles in animal models, but this work remains preclinical rather than validated through large human therapeutic trials [1112][1819]
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