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The efficacy and safety of tirzepatide, with a special focus on cardiovascular safety, were investigated in the 52-week SURPASS-4 trial testing tirzepatide versus insulin glargine in adults with T2D and a high cardiovascular risk under inadequate glycemic control at baseline on one to three oral glucose-lowering medications (metformin, sulfonylurea, SGLT-2 inhibitor) (74)
Excess body fat can affect hormone production, so weight loss from GLP-1 medications may improve some hormonal imbalances related to carrying extra weight
The male-to-female ratio was 1.56:1, suggesting a slight male prevalence of the disease
Diabetes Some research suggests L-carnitine has benefits for blood sugar management in people with diabetes
These findings show that GLP-1R signaling intersects with immune regulation pathways beyond metabolic control
