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392 However, an algorithm was developed to theoretically mitigate the risk of allopurinol hypersensitivity syndrome (AHS), which occurs in 28% of patients

Moreover, these analyses have already been done in conventional meta-analyses, showing for SGLT-2 inhibitors the lack of significant difference in the reduced risk of the composite outcome (CV death + HHF) in patients with or without type 2 diabetes or in subjects of 65 years of age or younger vs those older than 65 years of age [13]

Other options include pasireotide (which requires blood glucose monitoring due to hyperglycaemia risk), metyrapone , or ketoconazole (used off-label for Cushing's with liver function monitoring)

The answer is the ideal amount of B12 varies depending on factors like age