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Intrapelvic injection of GLP-1 with direct recording of afferent renal nerve activity (ARNA) Rats were anesthetized with urethane (0.75 g/kg, i.p.) and -chloralose (70 mg/kg, i.p.)
The fundamental dynamic that a small-molecule drug with multiple generic entrants will lose most of its revenue within 18 months of patent expiry is remarkably consistent across products and therapeutic categories
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These were not head-to-head studies, so the numbers should not be used to calculate precisely how much more effective the injection is
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