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doi: 10.1038/npp.2015.47, 61 HealthU
Tissue protection
The cartilage fragments resulting from these enzymes are subsequently recognized as danger signals by immune cells, which triggers intimal inflammation, known as synovitis, which feedbacks to further exacerbate the response (154)
The two therapies do not share metabolic pathways or compete for the same receptors, so combining them does not create pharmacological conflicts
Johannsson G, Marin P, Lonn L, et al
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