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These findings suggest that a GST tag is not an authentic TG2 substrate but instead is accidentally crosslinked by TG2 during cell lysate incubation

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doi:10.1016/S0140-6736(21)01751-7 DAscanio AM, Mullally JA, Frishman WH

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Providing your system with a high-bioavailability antioxidant during this window can help maintain the integrity of skin cells as they turn over