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Ferroptosis plays a crucial role in the occurrence and progression of various neurodegenerative diseases, including Alzheimers disease, Parkinsons disease, Huntingtons disease, and stroke ( Infectious pathogens often trigger oxidative stress responses in host cells, which can either facilitate pathogen infection or counteract it by promoting host cell death to halt infection progression

[22] Thus, NAD + is central to the aging process, which is why boosting NAD + is of particular interest in attenuating age-related decline

Haque R, Shi J, Schottinger JE, et al

It can actually be counterproductive

Plant Cell 12, 19391950