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The mechanism is unclear but may relate to rapid B12 mobilization in deficient patients
Short non-diabetic data support remaining at 2.5 mg when weight and insulin-resistance markers are already moving and tolerability favors a hold. The label still positions 2.5 mg as the starter before 5 mg, so it is a defensible low-dose floor for selected users rather than a replacement for the 5 mg obesity-trial floor
Explanation of key changes on 2022 WADA prohibited list
Disclaimer: MOTS-c is intended solely for laboratory research and in-vitro use
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