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Certain medications can interact with semaglutide or independently affect heart rate

Of these trials, four compared DPP-4 inhibitors against placebo (SAVOR-TIMI 53, EXAMINE, TECOS, CARMELINA), eight compared GLP-1RA against placebo (ELIXA, LEADER, SUSTAIN-6, EXSCEL, HARMONY, REWIND, PIONEER 6, AMPLITUTE-O) and eleven compared SGLT-2 inhibitors against placebo (EMPA-REG, CANVAS, DECLARE, CREDENCE, DAPA-HF, DAPA CKD, VERTIS-CV, EMPEROR-R, SCORED, SOLOIST-WHF, EMPEROR-P)

Beyond just energy, B12 can also support a more stable mood and may even help with symptoms of depression

Acknowledgements Special thanks for all study team for their dedication and support in this study

This means the same insulin dose may now be too much, increasing the risk of hypoglycemia