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Additive effects on weight loss were similarly demonstrated in the Efficacy and Safety of Semaglutide Once-weekly Versus Placebo as add-on to SGLT-2i in Subjects With Type 2 Diabetes Mellitus (SUSTAIN-9) and Dulaglutide as add-on therapy to SGLT2 inhibitors in patients with inadequately controlled type 2 diabetes (AWARD-10) trials [103,104]
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This effect is most pronounced after initial doses and diminishes with continued treatment
This patient had a complex medical history including peripheral neuropathy and chronic back pain, for which he was already taking pregabalin and duloxetine
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