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In vitro and in vivo studies have demonstrated the action of GLP1-RAs through the suppression of endothelin-1 at the vascular level by decreasing the phosphorylation of nuclear factor kappa B (NF-B) in the presence of elevated glucose concentrations, as occurs in patients with type 2 diabetes mellitus (DM2)
2 , 699706.e691 (2020)
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