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The most commonly reported concerns include inadequate protein intake, lean mass loss, vitamin D deficiency, thiamine and other B-vitamin issues, iron depletion, anemia, and low calcium, magnesium, and potassium intake

Nevertheless, the fact that DPP-4 is a key player in the clearance of both endogenous peptides has been exploited pharmacologically and, as mentioned above, DPP-4 inhibitors are now an established therapy of T2DM