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Extreme caloric restriction while on semaglutide can lead to muscle loss, nutritional deficiencies, and metabolic adaptation that makes long-term weight maintenance harder
A systematic review across 878 patients found mean body weight reductions of 14.33%, plus significant decreases in waist circumference (10.51 cm), fasting glucose, and blood pressure
But there are also people who we call the worried well healthy, but older people who dont want to leave this world prematurely who are already taking metformin, GLP-1, or rapamycin
In practical terms: Tirzepatide offers well-documented, steady metabolic support and weight-loss results
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