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Fluid and Electrolyte Concerns IV fluid may be inappropriate for some people with heart failure, kidney disease, severe hypertension, fluid restriction, or electrolyte disorders

5,6 DNA damage is also linked to neurodegenerative disorders, with the accumulation of DNA lesions in neurons being associated with Alzheimers, Huntingtons and Parkinsons diseases

There is only one clinical trial for lixisenatide in PD, assessing its efficacy in slowing motor disability progression in early-stage patients over 12 months, followed by a 2-month washout period

Who May Be at Greater Risk of Adverse Effects Over Time Older adults, people with prior pancreatitis or gallbladder disease, those with cardiovascular conditions or diabetic retinopathy, and individuals with renal impairment face heightened risk and require closer monitoring

Holt and colleagues 21 demonstrated that the stimulation of NTS GLP-1 neurons, as well as the direct application of GLP-1 onto the spinal cord increases heart rate