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However, no large-scale human clinical trials have confirmed these effects, so its use in people remains experimental and off-label

Addressing these challenges will likely require improved stratification of ASD models, increased use of cross-model validation, and a stronger focus on mechanistically informed and translationally relevant endpoints [ 134 ]

Hypertension The relationship between endothelial TJs and hypertension has been investigated for over four decades, revealing significant alterations in TJ integrity that contribute to vascular dysfunction

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For example, changes in the abundance of P.g , F.n , and Streptococcus spp., as well as their specific molecular markers, have been shown to correlate with the onset, progression, and severity of multiple diseases