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While known GLP-1R interactors such as G S , AP2, Rab5, and -arrestin 2 were reassuringly identified in our interactomics list, the most prominently enriched factor interacting with active GLP-1R was VAMP Associated Protein B (VAPB), followed by its homologue VAPA, integral ER proteins whose main role is the establishment and maintenance of organelle-ER interactions, or MCSs 12,13 , including those involving endosomes and/or mitochondria

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Peripheral metabolic effects In the pancreas, semaglutide stimulates glucose-dependent insulin secretion and suppresses glucagon release