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Reduced p27Kip-1 levels, often due to overexpression of the F-box protein Skp2, are associated with tumor progression and poor prognosis in various cancers

Hypoxia stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase through accumulation of lanosterol and hypoxia-inducible factor-mediated induction of insigs

[9] [14] Neurological symptoms associated with B12 deficiencysuch as paraesthesia, ataxia, or cognitive impairmentrequire urgent treatment with more frequent injections (1mg on alternate days initially) to prevent irreversible nerve damage

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the risk is lower than after malabsorptive procedures as no bowel is bypassed